Cerebral Micro-circulation and Red Blood Cells

  • Wan, Jiandi, et al. "Emerging Roles of Microfluidics in Brain Research: From Cerebral Fluids Manipulation to Brain-on-a-Chip and Neuroelectronic Devices Engineering." Chemical Reviews (2022). pdf
  • Noomuna, P., Risinger, M., Zhou, S., Seu K., Man Y., An, R., Sheik D., Wan J., Little J., Gurkan U., Turrini  F., Kalfa T., Low P. (2020) Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease. Br. J. Haematol. 190: 599-609. pdf
  • Zhou, S., Giannetto, M., DeCourcey, J., Kang, H., Kang, K., Li, Y., Zheng, S., Zhao, H., Simmons, WR., Wei, HS., Bodine, DM., Low, PS., Nedergaard*, M., Wan*, J. (2019) Oxygen tension–mediated erythrocyte membrane interactions regulate cerebral capillary hyperemia. Sci. Adv., EAAW4466. pdf
  • Smith, AS., Nowak, RB., Zhou, S., Gokhin, DS., Papoin, J., Ghiran, I., Blanc, L., Wan, J., Fowler*, VM. (2018) Myosin IIA interacts with the spectrin-actin 3 membrane skeleton to control the membrane curvature and deformability of red blood cells. Proc. Nat. Acad. Sci. USA, 115, E4377-85. pdf 
  • Chen, Y., Feng, Y., Wan, J., Chen,* H. (2018) Enhanced Separation of Aged RBCs by Designing Channel Cross Section. Biomicrofluidics. 12, 024106. Promoted as an Editor’s Pick. pdf
  • Zhou, S., Huang, YS., Cyr, KH., Palis, J., Wan,* J. (2017) Microfluidic assay of the deformability of primitive erythroblasts. Biomicrofluidics, 11, 054112. pdf
  • Chen, Y., Li, D., Zhang, C., Li, Y., Wan, J., Li, J., Chen,* H. (2017) Margination of Stiffened Red Blood Cells Regulated By Vessel Geometry. Sci Rep., 7: 15253. pdf
  • Huang, YS., Delgadillo, LF., Cyr, KH., Kingsley, PD., An, X., McGrath, KE., Narla, M., Conboy, JG., Waugh, RE., Wan, J., Palis,* J. (2017) Circulating primitive erythroblasts establish a functional, protein 4.1R-dependent cytoskeletal network prior to enucleating. Sci Rep., 7: 5164. pdf
  • Wei, H., Kang, H., Rasheed, IY., Luo, N., Zhou, S., Lou, N., Gershteyn, A., McConnel, E., Wang, Y., Richardson, K., Palmer, A., Xu, C., Wan,* J., Nedergaard,* M. (2016) Erythrocytes are oxygen-sensing regulators of the cerebral microcirculation. Neuron, 91, 851-862.  pdf
  • Cinar, E., Zhou S., DeCourcey, J., Wang, Y., Waugh, R.E., Wan,* J. (2015) Piezo1 regulates mechanotransductive release of ATP from human red blood cells. Proc. Nat. Acad. Sci. USA, 112, 11783-11788. pdf
  • Forsyth, A. M., Braunmüller, S., Wan, J., Franke, T., Stone, H. A. (2012) The effects of membrane cholesterol and simvastatin on red blood cell deformability and ATP release. Microvasc Res. 83, 347-351. pdf
  • Wan, J., Forsyth, A. M., and Stone, H. A. (2011) Red blood cell dynamics: from cell deformation to adenosine-5'-triphosphate release. Integr. Biol. 3, 972-981. Invited Review. pdf
  • Forsyth A. M., Wan, J., Owrutsky, P.D., Abkarian, M., and Stone, H. A. (2011) A multiscale approach to link red blood cell dynamics, shear viscosity, and ATP release. Proc. Nat. Acad. Sci. USA, 108, 10986-10991. pdf
  • Forsyth, A. M., Wan, J., Ristenpart, W. D., and Stone, H. A. (2010) The dynamic behavior of chemically “stiffened” red blood cells in microchannel flows. Microvasc Res.  80, 37-43. pdf
  • Stone, H.A., Forsyth, A. M., and Wan, J. (2009) Slipping through blood flow. Physics, 2, 89. pdf
  • Wan, J., Ristenpart, W. D., and Stone, H. A. (2008) Dynamics of shear-induced ATP release from red blood cells. Proc. Nat. Acad. Sci. USA. 105, 16432-16437. pdf


Organ-on-a-Chip and 3D Printing

  • Mea, Hing Jii, Luis Delgadillo, and Jiandi Wan. (2020) On-demand modulation of 3D-printed elastomers using programmable droplet inclusions. Proc. Nat. Acad. Sci. USA. 117, 14790-14797. pdf
  • Piou, M., Fan, R., Darling, E., Cormier, D., Sun,* J., Wan,* J. (2016) Bioprinting cell-laden Matrigel/agarose constructs. J. Biomater Appl., 0885328216669238. pdf
  • Fan, R., Emery, T., Zhang, Y., Xia, Y., Sun,* J., Wan,* J. (2016) Circulatory shear flow alters the viability and proliferation of circulating colon cancer cells. Sci Rep., 6, 27073. pdf
  • Fan, R., Sun, Y., Wan,* J. (2015) Leaf-inspired artificial microvascular networks (LIAMN) for 3D cell culture. RSC Advances. 5, 90596-90601. pdf
  • Wu, S., Yoon, S., Zhang, Y. G., Lu, R., Xia, Y., Wan, J., Petrof, E. O., Claud, E. C., Sun,* J. (2015) Vitamin D receptor pathway is required for probiotic protection in colitis. Am J Physiol Gastrointest Liver Physiol. 309, G341-9. 
  • Fan, R., Naqvi, K., Patel, K.,  Sun, J., Wan,* J. (2015) Microfluidic generation of oil-free cell-containing hydrogel particles. Biomicrofluidics. 9, 052602. pdf
  • Wan,* J., (2012) Microfluidic-based synthesis of hydrogel particles for cell microencapsulation and cell-based drug delivery. Polymers, 4, 1084-1108. Invited Review. pdf
  • Wan, J., Thomas, M., and Vullev, V. I. (2009) Surface bound proteins with preserved functionality. Ann. Biomed. Eng. 37, 1190-1205. pdf


Microfluidics and Electrochemistry

  • Ma, M. C., Li, G., Chen, X., Archer, L. A., & Wan, J. (2021). Suppression of dendrite growth by cross-flow in microfluidics. Science Advances, 7(8), eabf6941. pdf
  • Chang, Y., Chen, X., Zhou, Y., Wan, J. (2019) Deformation-based droplet separation in microfluidics." Ind. Eng. Chem. Res. 59, 3916–3921. pdf
  • Fan, R., Chen, X., Wang, Z., Custer, D., Wan,* J. (2017) Flow-regulated growth of titanium dioxide (TiO2) nanotubes in microfluidics. Small, 13, 1701154. (Featured as a frontispiece article). pdf
  • Fan, R., Wan,* J. (2017) Electrode distance regulates the anodic growth of titanium dioxide (TiO2 ) nanotubes. Nanotechnology, 28, 25LT01. pdf
  • Lu, T., Fan, R., Delgadillo, L., Wan,* J. (2016) Stabilization of carbon dioxide (CO2) bubbles in micrometer-diameter aqueous droplets and the formation of hollow microparticles. Lab On Chip. 16, 1587-1592. (Featured as a cover article). pdf
  • Koppula, K. S., Veerapalli, K. R., Fan, R., Wan,* J. (2016) Integrated microfluidic system with simultaneous emulsion generation and concentration. J Colloid Interface Sci., 466, 162-167.  pdf
  • Ge, H. Xu, H., Lu, T., Li, J., Chen, H., Wan,* J. (2015) Microfluidic production of porous carbon spheres with tunable size and pores. J Colloid Interface Sci., 461, 168-172. pdf
  • Li, J., Wang, Y., Chen,* H., Wan, J. (2014) Electrowetting on dielectrics for manipulating oil drops and gas bubbles in aqueous-shell compound drops. Lab on Chip. 14, 4334-4337. pdf
  • Shim, S., Wan, J., Hilgenfeldt, S., Panchal, P., Stone,* H. A. (2014) Dissolution without disappearing: multicomponent gas exchange for CO2 bubbles in a microfluidic channel. Lab On Chip. 14, 2428–2436. pdf
  • Nunes, J. K., Tsai, S. S. H., Wan, J., Stone,* H. A. (2013) Dripping and jetting in microfluidic multiphase flows applied to particle and fiber synthesis. J. Phys. D: Appl. Phys. 46, 114002. pdf
  • Chen, H., Li, J., Wan, J., Weitz, D. A., and Stone,* H. A. (2013) Gas-core triple emulsions for ultrasound triggered release. Soft Matter. 9, 38-42. (Featured as a cover article). pdf
  • Tsai, S. S. H., Wexler, J. S., Wan, J, and Stone,* H. A. (2013) Microfluidic ultralow interfacial tensiometry by magnetic forcing. Lab On Chip. 13, 119-125.
  • Wan,* J., Shi, L., Benson, B., Bruzek, M. J., Anthony, J. E., Sinko, P. J., Prudhomme, R. K., and Stone,* H. A. (2012) Microfluidic generation of droplets with a high-loading of nanoparticles. Langmuir. 28, 13143–13148. pdf
  • Wan, J., and Stone, H. A. (2012) Coated gas bubbles for the continuous synthesis of hollow inorganic particles. Langmuir. 28, 37–41. pdf
  • Tsai, S. S. H., Wexler, J. S., Wan, J, and Stone, H. A. (2011) Conformal coating of particles in microchannels by magnetic forcing. Appl. Phys. Lett. 99, 153509. pdf
  • Chen, H., Zhao, Y., Li, J., Guo, M., Wan, J., Weitz, D. A., Stone, H. A. (2011) Reactions in double emulsions by flow-controlled coalescence of encapsulated drops. Lab On Chip. 11, 2312-2315. pdf
  • Subramaniam, A. B., Wan, J., Gopinath, A., and Stone, H. A. (2011) Semipermeable vesicles composed of natural clay. Soft Matter. 7, 2600–2612. pdf
  • Wan, J., and Stone, H. A. (2010) Microfluidic generation of a high volume fraction of bubbles in droplets. Soft Matter. 6, 4677-4680. (Featured as a cover article). pdf
  • Wan, J., Bick, A., Sullivan, M., and Stone, H. A. (2008) Controllable microfluidic production of microbubbles in water-in-oil emulsions and the formation of porous microparticles. Adv. Mater. 20, 3314-3318. pdf
  • Ristenpart, W. D., Wan, J., and Stone, H. A. (2008) Enzymatic reactions in microfluidic devices. Anal. Chem. 80, 3270-3276. pdf
  • Ristenpart, W. D., Kim, P. G., Donmingues, C., Wan, J., and Stone, H. A. (2007) Influence of substrate conductivity on circulation reversal in evaporating drops. Phys. Rev. Lett. 99, 234502. pdf
  • Vullev, V. I., Wan, J., Heinrich, V., Landsman, P., Bower, P. E., Xia, B.,  Millare, B., and Jones II, G. (2006) Nonlithographic fabrication of microfluidic devices. J. Am. Chem.  Soc. 128, 16062-16072. pdf

Devices and Technology Development

  • Wan, J., Fan, R., Wang, Z. (2020) Flow-regulated growth of TiO2 nanotubes. US Patent. US20180038006A1.
  • Prud'homme, R., Sinko, P. J., Stone, H. A., Pinkerton, N. M.., Shi, L., Wan, J., Ibrahim, S. and Gao, D. (2010) Lung Targeting Dual Drug Delivery System. US Patent. US 9421194B2.